Phenotypes Associated with This Genotype

Genotype
MGI:5499989

• Allelic Composition: Apoe^tm1Khw/Apoe^tm1Khw; Tg(Mx1-cre)29-4Her/0
• Genetic Background: B6.Cg-Apoe^tm1Khw Tg(Mx1-cre)29-4Her

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating lipid level ( J:196923 )

• mice fed a high cholesterol diet exhibit increased in all lipid classes, phospholipid, free cholesterol, cholesterol esters and triglycerides in the VLDL fractions compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

increased circulating cholesterol level ( J:196923 )

• at least 2-fold in mice fed a high cholesterol diet

• modest increase in female, but not male, mice fed a high cholesterol diet at 4 and 12 weeks compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

increased circulating VLDL cholesterol level ( J:196923 )

• in mice fed a high cholesterol diet compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

hyperlipidemia ( J:196923 )

• female mice fed a high cholesterol diet develop hypercholesterolemia faster than male mice

abnormal apolipoprotein level ( J:196923 )

• macrophages release reduced ApoE compared with macrophages from Apoe^tm1Rraf homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:196923 )

• in the descending aorta of mice fed a high cholesterol diet compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

• however, lesion formation in the aortic arch is equivalent

immune system

immune system phenotype ( J:196923 )

N • leukocyte levels are not altered