Phenotypes Associated with This Genotype

Genotype
MGI:5499855

• Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:198845 )

• mice die within 3 weeks of birth

skeleton

increased skeletal tumor incidence ( J:198845 )

• tumor-like cells in the femur

decreased bone mineral density ( J:198845 )

abnormal compact bone morphology ( J:198845 )

• increased cortical porosity

decreased compact bone area ( J:198845 )

decreased compact bone thickness ( J:198845 )

abnormal trabecular bone morphology ( J:198845 )

• reduced trabecular bone density

decreased trabecular bone volume ( J:198845 )

decreased bone trabecula number ( J:198845 )

decreased trabecular bone connectivity density ( J:198845 )

growth/size/body

decreased body weight ( J:198845 )

postnatal growth retardation ( J:198845 )

homeostasis/metabolism

hypoglycemia ( J:198845 )

neoplasm

increased skeletal tumor incidence ( J:198845 )

• tumor-like cells in the femur