Phenotypes for Hdac6 MGI:5499210 MGI Mouse

reproductive system

reproductive system phenotype ( J:132629 )

N	• mice are fertile and exhibit normal fertilization

immune system

immune system phenotype ( J:132629 )

N	• despite modest effects to immune response, mice exhibit normal lymphocyte develpment

decreased IgG level ( J:132629 )

• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

decreased IgM level ( J:132629 )

• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

skeleton

increased bone mineral content ( J:132629 )

• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice

increased bone mineral density ( J:132629 )

• cancellous bone mineral density is moderately increased compared to wild-type mice

• however, after 3 months bone mineral density is normal

growth/size/body

increased body weight ( J:132629 )

• at 3 months

nervous system

nervous system phenotype ( J:132629 )

N	• mice exhibit normal brain and spinal cord morphology

hematopoietic system

decreased IgG level ( J:132629 )

• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

decreased IgM level ( J:132629 )

• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23