Phenotypes Associated with This Genotype

Genotype
MGI:5498468

• Allelic Composition: b2b1511Clo/b2b1511Clo
• Genetic Background: C57BL/6J-b2b1511Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1511-006-1 (E16.5) exhibits right aortic arch (RAA), pulmonary stenosis and malalignment of the great arteries, which was shown to be double outlet right ventricle (DORV) by histopathology

cardiovascular system

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

double outlet right ventricle ( J:175213 )

ventricular septal defect ( J:175213 )

perimembraneous ventricular septal defect ( J:175213 )

muscular ventricular septal defect ( J:175213 )

craniofacial

cleft palate ( J:175213 )

facial cleft ( J:175213 )

limbs/digits/tail

polydactyly ( J:175213 )

renal/urinary system

kidney cyst ( J:175213 )

hydronephrosis ( J:175213 )

duplex kidney ( J:175213 )

hydroureter ( J:175213 )

vision/eye

microphthalmia ( J:175213 )

anophthalmia ( J:175213 )

digestive/alimentary system

cleft palate ( J:175213 )

growth/size/body

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

cleft palate ( J:175213 )

facial cleft ( J:175213 )

kidney cyst ( J:175213 )

muscle

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )