Phenotypes Associated with This Genotype

Genotype
MGI:5497000

• Allelic Composition: Slc18a2^tm1.1Bgir/Slc18a2^tm1.1Bgir; Slc6a4^tm1(cre)Xz/Slc6a4⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:197966 )

• some mice die between P1 and P30

behavior/neurological

abnormal emotion/affect behavior ( J:197966 )

• in a tail suspension test, mice exhibit an increase in active defense behavior indicated by increased time spent struggling to escape and decreased immobilization compared with wild-type mice

• in response to aversive ultrasonic stimulus, mice exhibit a large increase in behavioral reactivity with less freezing compared with wild-type mice

• however, mice treated with pargyline exhibit normal flight responses in response to ultrasonic stimulus

decreased anxiety-related response ( J:197966 )

• in a novelty-suppressed feeding test, mice exhibit faster initiation of feeding compared with wild-type mice

decreased locomotor activity ( J:197966 )

• in an elevated plus maze

homeostasis/metabolism

abnormal catecholamine level ( J:197966 )

• decreased in the hippocampus but not the cortex or striatum

decreased serotonin level ( J:197966 )

• in the brain (cortex, striatum and brain stem) and blood

• mice treated with pargyline exhibit lower 5-HT levels compared with wild-type mice

• however, mice exhibit normal 5-HIAA brain levels and serotonin gut levels

nervous system

nervous system phenotype ( J:197966 )

N • 5-HT raphe neurons develop normally