Phenotypes Associated with This Genotype

Genotype
MGI:5496896

• Allelic Composition: Stk11^tm1Rdp/Stk11^tm1Rdp; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

decreased tumor latency ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)

integument

abnormal mammary gland morphology ( J:198481 )

♀ • tissue adjacent to primary tumors display abnormal luminal growth, possibly an early sign of tumors

increased mammary gland tumor incidence ( J:198481 )

♀ • 50% of nulliparous female mice develop tumors by 147 days of age, compared to nulliparous wild-type females which do not develop tumors (during period of observation)