Phenotypes Associated with This Genotype

Genotype
MGI:5496363

• Allelic Composition: Fcmr^tm1Mak/Fcmr^tm1Mak
• Genetic Background: B6.129S2-Fcmr^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194323 )

N • granulocyte and monocyte differentiation is normal

abnormal granulocyte physiology ( J:194323 )

• production of active oxygen species (ROS) and degranulation occur with increased frequency

• 50% of mutant granulocytes respond to stimulation with N-formyl-methionine-leucine-phenylalanine (fMLP) compared to 10% of control cells

• similar results when stimulated by LPS, GM-CSF, or reduced temperature

impaired granulocyte bactericidal activity ( J:194323 )

• reduced binding, uptake, and phagocytosis of Listeria monocytogenes by granulocytes but only in the presence of serum IgM

• reduced binding in the absence of IgM is comparable to control granulocytes

immune system

abnormal granulocyte physiology ( J:194323 )

• production of active oxygen species (ROS) and degranulation occur with increased frequency

• 50% of mutant granulocytes respond to stimulation with N-formyl-methionine-leucine-phenylalanine (fMLP) compared to 10% of control cells

• similar results when stimulated by LPS, GM-CSF, or reduced temperature

impaired granulocyte bactericidal activity ( J:194323 )

• reduced binding, uptake, and phagocytosis of Listeria monocytogenes by granulocytes but only in the presence of serum IgM

• reduced binding in the absence of IgM is comparable to control granulocytes

abnormal cytokine secretion ( J:194323 )

decreased interleukin-6 secretion ( J:194323 )

• decreased IL-6 production

decreased tumor necrosis factor secretion ( J:194323 )

• decreased TNF-alpha production

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:194323 )

• granulocytes are resistant to LPS induced mortality

increased susceptibility to bacterial infection ( J:194323 )

• increased titers of Listeria in spleen, liver, and brain tissue 3 days after infection

• increased number of bacteria in granulomas

• increased myeloperoxidase in serum after Listeria infection of live mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:194323 )

• increased mortality due to Listeria infection

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:194323 )

• granulocytes are resistant to LPS induced mortality

increased susceptibility to bacterial infection induced morbidity/mortality ( J:194323 )

• increased mortality due to Listeria infection