Phenotypes Associated with This Genotype

Genotype
MGI:5496263

• Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1*)Dtg}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:196002 )

• fewer than expected mice are born

growth/size/body

decreased birth body size ( J:196002 )

decreased body weight ( J:196002 )

postnatal growth retardation ( J:196002 )

immune system

increased circulating interleukin-1 alpha level ( J:196002 )

increased circulating interleukin-1 beta level ( J:196002 )

increased circulating tumor necrosis factor level ( J:196002 )

behavior/neurological

circling ( J:196002 )

• around body axis

integument

integument phenotype ( J:196002 )

N • mice exhibit normal skin without ulceration, necrosis or inflammation

nervous system

nervous system phenotype ( J:196002 )

N • brain tissue is normal under MRI and histological examination

skeleton

skeleton phenotype ( J:196002 )

N • unlike patients with PAPA, mice do not exhibit signs of arthritis

homeostasis/metabolism

increased circulating interleukin-1 alpha level ( J:196002 )

increased circulating interleukin-1 beta level ( J:196002 )

increased circulating tumor necrosis factor level ( J:196002 )