Phenotypes Associated with This Genotype

Genotype
MGI:5496260

• Allelic Composition: Lrsam1^{Gt(RRK461)Byg}/Lrsam1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal limb posture ( J:196447 )

• paws turn outward

• wider stance than control, however gait, stride time, stance time and swing time are similar to control

nervous system

abnormal axon morphology ( J:196447 )

• number of axons in the motor branch of the femoral nerve is slightly reduced at >12 months of age compared to controls, although cross-sectional area of axons is unchanged

• average axon diameter in the sensory branch of the femoral nerve is slightly decreased at >12 months of age compared to controls

• number of motor axons in the femoral nerve are reduced in 5 month old mice treated with the neurotoxic agent acrylamide

abnormal neuromuscular synapse morphology ( J:196447 )

• area of neuromuscular junction in the bone region of the tibialis anterior muscle is increased at 5 months of age, but is similar to control at > 12 months of age