About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5496257
Allelic
Composition
Lrsam1Gt(RRK461)Byg/Lrsam1Gt(RRK461)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrsam1Gt(RRK461)Byg mutation (1 available); any Lrsam1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number of axons in the motor branch of the femoral nerve is slightly reduced at >12 months of age compared to controls, although cross-sectional area of axons is unchanged
• average axon diameter in the sensory branch of the femoral nerve is slightly increased at >12 months of age compared to controls
• 5 month old mice treated with the neurotoxic agent acrylamide have reduced axon cross-sectional areas in the motor branch of the femoral nerve, suggesting a loss of large diameter axons
• area of neuromuscular junction of the tibialis anterior muscle is increased at 5 months of age, but is similar to control at > 12 months of age
• peripheral motor axons exhibit increased sensitivity to acrylamide-induced degeneration
• untreated mice exhibit modest differences in neuromuscular junction area and axon number
• decrease in nerve conduction velocity is observed in 5 month old mice treated with the neurotoxic agent acrylamide for two weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease axonal type 2P DOID:0110169 OMIM:614436
J:196447


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/07/2020
MGI 6.14
The Jackson Laboratory