Phenotypes for Bmi1 Gt(ROSA)26Sor MGI:5495321 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^{tm1(cre/ERT)Mrc} mutation (2 available); any Bmi1 mutation (33 available)
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (1060 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:194308 )

• fully penetrant tumorigenesis when tamoxifen is injected after 3 weeks of age

• tumors in deep mesenchymal tissues of the limbs and trunk

• most tumors form adjacent to bone but some are totally in muscle

• all tumors with "clear cell" morphology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/30/2025 MGI 6.24