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Phenotypes Associated with This Genotype
Genotype
MGI:5495282
Allelic
Composition		 Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1062 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
Wnt1tm1.1Mze mutation (0 available); any Wnt1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
premature neuronal precursor differentiation ( J:194842 )
• significant increase of the number of differentiated MbDA neurons at E11.5
• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes
abnormal midbrain morphology ( J:194842 )
• depletion of medial MbDA neurons and expansion of more laterally positioned MbDA neurons at E12.5
decreased neuron number ( J:194842 )
• depletion of medial MbDA neurons

cellular
premature neuronal precursor differentiation ( J:194842 )
• significant increase of the number of differentiated MbDA neurons at E11.5
• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory