Phenotypes Associated with This Genotype

Genotype
MGI:5495280

• Allelic Composition: Wnt1^tm1.1Mze/Wnt1^tm1.1Mze; Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal rhombomere morphology ( J:194842 )

• rhombomere 1 is diminished with only a small domain adjacent to axonal bundles connected to the trigeminal ganglia

• dorsal rhombomere 1 is severely depleted but the ventral portion is less severely affected

abnormal midbrain morphology ( J:194842 )

• substantial depletion of the En1 lineage derived mesencephalon at E12.5

• dorsal mesencephalon is severely depleted but the ventral portion is less severely affected

abnormal hindbrain morphology ( J:194842 )

• severe truncation of the lateral anterior hindbrain

abnormal innervation ( J:194842 )

• aberrantly patterned whisker fields innervated by serotonergic neurons

decreased neuronal precursor cell number ( J:194842 )

• absence of LMX1a+ progenitors throughout the medial-lateral extent of the ventral mesencephalon and decreased numbers in the ventral diencephalon

decreased neuron number ( J:194842 )

• only a small disorganized cohort of TH+ MbDA neurons remain at E8.5

embryo

abnormal rhombomere morphology ( J:194842 )

• rhombomere 1 is diminished with only a small domain adjacent to axonal bundles connected to the trigeminal ganglia

• dorsal rhombomere 1 is severely depleted but the ventral portion is less severely affected