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Phenotypes Associated with This Genotype
Genotype
MGI:5494567
Allelic
Composition
Ftotm1.1Rdc/Ftotm1.1Rdc
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftotm1.1Rdc mutation (2 available); any Fto mutation (76 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (11 available); any Ndor1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 3 of 25 mice die over the 14 weeks after tamoxifen treatment compared with 1 control mouse

homeostasis/metabolism
N
• tamoxifen-treated male mice exhibit normal oxygen consumption and energy expenditure
• in tamoxifen-treated male mice during the light and dark phases when adjusted for lean body mass
• in tamoxifen-treated male mice during the light and dark

growth/size/body
• in tamoxifen-treated male mice at 9 and 20 weeks
• in tamoxifen-treated male mice at 20 weeks

adipose tissue
• in tamoxifen-treated male mice at 20 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory