Phenotypes Associated with This Genotype

Genotype
MGI:5494310

• Allelic Composition: Sppl2a^m1Anu/Sppl2a^m1Anu
• Genetic Background: involves: C57BL/6JAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal transitional stage B cell morphology ( J:194663 )

• 20 fold reduction of CD93^- IgM^low cells

decreased transitional stage T2 B cell number ( J:194663 )

• 20 fold reduction

decreased transitional stage T3 B cell number ( J:194663 )

• 20 fold reduction

abnormal mature B cell morphology ( J:194663 )

• number of mature IgD⁺ IgM^low recirculating B cells is selectively decreased and have very low levels of cell surface IgD

• 12% of normal levels of IgD and 30% of normal IgM on the cell surface

decreased marginal zone B cell number ( J:194663 )

• reduced 200 fold but localization to primary follicles is normal

abnormal immunoglobulin level ( J:194663 )

• almost no specific antibodies after immunization with various antigens

decreased IgG1 level ( J:194663 )

• serum levels decreased 6 fold

decreased IgM level ( J:194663 )

• serum levels decreased 25 fold

• cell surface levels are normal

hematopoietic system

hematopoietic system phenotype ( J:194663 )

N • normal bone marrow cellularity

N • normal pro-B, pre-B, and immature B cells

abnormal transitional stage B cell morphology ( J:194663 )

• 20 fold reduction of CD93^- IgM^low cells

decreased transitional stage T2 B cell number ( J:194663 )

• 20 fold reduction

decreased transitional stage T3 B cell number ( J:194663 )

• 20 fold reduction

abnormal mature B cell morphology ( J:194663 )

• number of mature IgD⁺ IgM^low recirculating B cells is selectively decreased and have very low levels of cell surface IgD

• 12% of normal levels of IgD and 30% of normal IgM on the cell surface

decreased marginal zone B cell number ( J:194663 )

• reduced 200 fold but localization to primary follicles is normal

abnormal immunoglobulin level ( J:194663 )

• almost no specific antibodies after immunization with various antigens

decreased IgG1 level ( J:194663 )

• serum levels decreased 6 fold

decreased IgM level ( J:194663 )

• serum levels decreased 25 fold

• cell surface levels are normal