Phenotypes Associated with This Genotype

Genotype
MGI:5492110

• Allelic Composition: Tg(Adora2a-Chrm3*,-mCherry)AD6Blr/?
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:191042 )

• clozapine-N-oxide (CNO) co-administered with amphetamine inhibits behavioral sensitization

• behavioral sensitization is similar in mutant and controls following administration of amphetamine without CNO

decreased locomotor activity ( J:191042 )

• following administration of CNO, mice exhibit decreased locomotion in an open field testing chamber

• spontaneous locomotion is decreased during active period (dark phase) after CNO treatment

nervous system

abnormal glutamate-mediated receptor currents ( J:191042 )

• CNO co-administered with amphetamine during induction of behavioral sensitization results in a long-lasting increase in the AMPAR/NMDAR receptor ratio in medium spiny neurons expressing Adora2a