Phenotypes for Ctsk Tg(Itgam-cre)AJva MGI:5492066 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsk^tm1.1Rbar mutation (0 available); any Ctsk mutation (30 available)
Tg(Itgam-cre)AJva mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increase in cancellous bone mass in Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 mice

skeleton

increased osteoclast cell number ( J:194492 )

increased bone volume ( J:194492 )

• increased femoral cross-sectional bone volume

increased compact bone volume ( J:194492 )

increased trabecular bone volume ( J:194492 )

increased osteoblast cell number ( J:194492 )

increased trabecular bone mass ( J:194492 )

increased trabecular bone thickness ( J:194492 )

increased bone mineralization ( J:194492 )

• increased mineral apposition

increased bone ossification ( J:194492 )

• increased bone formation

immune system

increased osteoclast cell number ( J:194492 )

hematopoietic system

increased osteoclast cell number ( J:194492 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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