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Phenotypes Associated with This Genotype
Genotype
MGI:5492044
Allelic
Composition		 Hsd17b11Gt(OST237628)Lex/Hsd17b11Gt(OST237628)Lex
Genetic
Background		 B6;129S5-Hsd17b11Gt(OST237628)Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd17b11Gt(OST237628)Lex mutation (1 available); any Hsd17b11 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased immature B cell number ( J:171883 )
• homozygotes exhibit an increased mean percentage of immature B cells in bone marrow
increased IgG2a level ( J:171883 )
• homozygous mice exhibit an increased mean serum IgG2a response to ovalbumin challenge

immune system
increased immature B cell number ( J:171883 )
• homozygotes exhibit an increased mean percentage of immature B cells in bone marrow
increased IgG2a level ( J:171883 )
• homozygous mice exhibit an increased mean serum IgG2a response to ovalbumin challenge

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory