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Phenotypes Associated with This Genotype
Genotype
MGI:5491627
Allelic
Composition
Tg(Thy1-APPSweLon)41Ema/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species
• progressive loss of synaptophysin-immunoreactive presynaptic terminals in the frontal cortex beginning at 3-4 months of age and in the hippocampus beginning at 5-7 months of age

hematopoietic system

immune system

homeostasis/metabolism
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:162842


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory