Phenotypes Associated with This Genotype

Genotype
MGI:5490888

• Allelic Composition: Stra6^tm1Nbg/Stra6^tm1Nbg
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina cone cell number ( J:196841 )

• at 6 weeks and worse at 5 months

short photoreceptor inner segment ( J:196841 )

short photoreceptor outer segment ( J:196841 )

persistent hyperplastic primary vitreous ( J:196841 )

• through 10 months of age

microphthalmia ( J:196841 )

• slight reduction in eye diameter at 6 weeks that persists at 5 and 10 months

abnormal cone electrophysiology ( J:196841 )

• reduced b-wave cone response that does not change with age

abnormal rod electrophysiology ( J:196841 )

• reduced scotopic a- and b-wave amplitudes even in mice with unilateral persistent hyperplastic primary vitreous

homeostasis/metabolism

abnormal retinol level ( J:196841 )

• amounts of all-trans-retinal and other retinol derivatives are reduced in the retinal pigment epithelium and retina

• however, dark-adaptation allows for partial regeneration of 11-cis-RAL levels

nervous system

decreased retina cone cell number ( J:196841 )

• at 6 weeks and worse at 5 months

short photoreceptor inner segment ( J:196841 )

short photoreceptor outer segment ( J:196841 )