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Phenotypes Associated with This Genotype
Genotype
MGI:5490548
Allelic
Composition
Siglecetm1Croc/Siglecetm1Croc
Genetic
Background
B6.129P2-Siglecetm1Croc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siglecetm1Croc mutation (0 available); any Siglece mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice
• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice
• however, blockage of CD11B reverses increased recruitment in LPS-treated mice
• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice

hematopoietic system
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice
• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice
• however, blockage of CD11B reverses increased recruitment in LPS-treated mice
• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory