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Phenotypes Associated with This Genotype
Genotype
MGI:5490536
Allelic
Composition		 Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (74 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
Tg(SFTPC-rtTA)5Jaw mutation (5 available)
Tg(tetO-cre)1Jaw mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:196943 )
• increased phosphatidylcholine in the bronchoalveolar lavage fluid of doxycycline-treated mice
increased cholesterol level ( J:196943 )
• in the bronchoalveolar lavage fluid of doxycycline-treated mice

respiratory system
increased surfactant secretion ( J:196943 )
• increased surfactant protein A, B, C and D in the whole lung lysate of doxycycline-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory