mortality/aging
• most animals survive through gestation, but most survivors die within 8 weeks of birth likely as result of compromised cardiac function
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cardiovascular system
• edematous embryos at E13.5-14.5 have enlarged hearts
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• affected mutants phenocopy Fkbp1atm1Zuk mice, showing ventricular hypertrabeculation and noncompaction
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• observed in affected mutants at E13.5-14.5
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• prominent defects (both membranous and muscular) in origin are observed in ~40% of affected embryos at E13.5-14.5
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• affected embryos at E13.5-14.5 have hearts that are that are 'pumpkin-shaped', lacking the ventricular groove
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• edematous (affected) embryos at E13.5-14.5 show signs of failing hearts
• surviving mice at 8 weeks display compromised cardiac function
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homeostasis/metabolism
growth/size/body
• edematous embryos at E13.5-14.5 have enlarged hearts
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muscle
• observed in affected mutants at E13.5-14.5
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