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Phenotypes Associated with This Genotype
Genotype
MGI:5490245
Allelic
Composition
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp1atm1.1Shou mutation (0 available); any Fkbp1a mutation (12 available)
Fkbp1atm1Zuk mutation (0 available); any Fkbp1a mutation (12 available)
Tg(Tek-cre)1Ywa mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most animals survive through gestation, but most survivors die within 8 weeks of birth likely as result of compromised cardiac function

cardiovascular system
• edematous embryos at E13.5-14.5 have enlarged hearts
• affected mutants phenocopy Fkbp1atm1Zuk mice, showing ventricular hypertrabeculation and noncompaction
• observed in affected mutants at E13.5-14.5
• prominent defects (both membranous and muscular) in origin are observed in ~40% of affected embryos at E13.5-14.5
• affected embryos at E13.5-14.5 have hearts that are that are 'pumpkin-shaped', lacking the ventricular groove
• edematous (affected) embryos at E13.5-14.5 show signs of failing hearts
• surviving mice at 8 weeks display compromised cardiac function

homeostasis/metabolism
• about 1/3 of embryos at E13.5-14.5 are edematous

growth/size/body
• edematous embryos at E13.5-14.5 have enlarged hearts

muscle
• observed in affected mutants at E13.5-14.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory