Analysis Tools
mortality/aging
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• fewer than expected mice are present after weaning
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• defective mice die shortly after birth
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reproductive system
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• in female mice fed a folic acid deficient diet
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embryo
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• at E9.5, somite number varied between 6 and 22 indicating developmental delay
• in 30 of 37 mice from dams fed a folic acid-free diet
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• craniofacial mesenchyme is less densely packed with fewer interconnections, increased extracellular space and more abundant clusters of blood cells compared with wild-type mice
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• at the 21-somite stage, the inner surface of the neuroepithelium is convex and the edges of the neural folds are pointing towards the outside
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• in 1 of 6 12-somite mice
• in the cranial neural tube of most mice at the 14-somite stage
• in 30% of mice from dams fed a folic acid-free diet unlike wild-type mice
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craniofacial
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• in some mice with increased cell death in the forehead spreading laterally and dorsally
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• in some mice at E18.5
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vision/eye
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• at E18.5 in some mice
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cellular
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• increased cell death of craniofacial cells in the forehead spreading laterally and dorsally
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growth/size/body
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• in some mice at E18.5
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• at E9.5, somite number varied between 6 and 22 indicating developmental delay
• in 30 of 37 mice from dams fed a folic acid-free diet
|
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• craniofacial mesenchyme is less densely packed with fewer interconnections, increased extracellular space and more abundant clusters of blood cells compared with wild-type mice
|
nervous system
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• at the 21-somite stage, the inner surface of the neuroepithelium is convex and the edges of the neural folds are pointing towards the outside
|
|
• in 1 of 6 12-somite mice
• in the cranial neural tube of most mice at the 14-somite stage
• in 30% of mice from dams fed a folic acid-free diet unlike wild-type mice
|
exencephaly
(
J:163651
)
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• in some mice at E18.5
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