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Phenotypes Associated with This Genotype
Genotype
MGI:5488614
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (24 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:194748 )
• fewer B lineage progenitors
decreased bone marrow cell number ( J:194748 )
• significant reduction in bone marrow cellularity
• reduced frequency of hematopoietic stem cells, CLP and IL7RalphaLMPP cells

immune system
abnormal B cell differentiation ( J:194748 )
• fewer B lineage progenitors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory