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Phenotypes Associated with This Genotype
Genotype
MGI:5488511
Allelic
Composition		 X/Tg(Tlr7)6Boll
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased splenocyte proliferation ( J:127600 )
• hyperresponsive to imiquimod induced splenocyte proliferation
enlarged spleen ( J:127600 )
• detected in 8 of 8 mice
abnormal dendritic cell morphology ( J:127600 )
• greater than 10% CD11c+ cells in the blood of all mice
decreased marginal zone B cell number ( J:127600 )
• at 2 - 3 months of age
increased mature B cell number ( J:127600 )
• increase in the B220lo CD138+ population of B cells
abnormal B cell activation ( J:127600 )
• show spontaneous activation
abnormal T cell activation ( J:127600 )
• show spontaneous activation
autoimmune response ( J:127600 )
• autoantibodies show a nuclear, nucleolar or mixed pattern
increased anti-nuclear antigen antibody level ( J:127600 )
• increase in anti-RNA IgG levels in 8 of 9 mice
liver inflammation ( J:127600 )
• detected in 3 of 8 mice
glomerulonephritis ( J:127600 )
• detected in 6 of 8 mice
lung inflammation ( J:127600 )
• detected in 2 of 8 mice

hematopoietic system
increased splenocyte proliferation ( J:127600 )
• hyperresponsive to imiquimod induced splenocyte proliferation
enlarged spleen ( J:127600 )
• detected in 8 of 8 mice
abnormal dendritic cell morphology ( J:127600 )
• greater than 10% CD11c+ cells in the blood of all mice
decreased marginal zone B cell number ( J:127600 )
• at 2 - 3 months of age
increased mature B cell number ( J:127600 )
• increase in the B220lo CD138+ population of B cells
abnormal B cell activation ( J:127600 )
• show spontaneous activation
abnormal T cell activation ( J:127600 )
• show spontaneous activation

liver/biliary system
liver inflammation ( J:127600 )
• detected in 3 of 8 mice

renal/urinary system
glomerulonephritis ( J:127600 )
• detected in 6 of 8 mice

cellular
increased splenocyte proliferation ( J:127600 )
• hyperresponsive to imiquimod induced splenocyte proliferation

respiratory system
lung inflammation ( J:127600 )
• detected in 2 of 8 mice

growth/size/body
enlarged spleen ( J:127600 )
• detected in 8 of 8 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory