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Phenotypes Associated with This Genotype
Genotype
MGI:5488509
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (23 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:127600 )
• moribund at 5 months of age

immune system
autoimmune response ( J:127600 )
• autoantibodies show a nucleolar pattern
increased anti-nuclear antigen antibody level ( J:127600 )
• marked increase in anti-RNA IgG levels in the serum at 4 - 6 months of age

renal/urinary system
abnormal kidney morphology ( J:127600 )
• kidney disease

hematopoietic system

growth/size/body
enlarged spleen ( J:127600 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory