Analysis Tools
mortality/aging
 |
• survival is prolonged compared to mutant mice wild-type for Tlr7
|
immune system
|
|
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
|
|
|
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7
|
|
|
• autoantibodies show a homogeneous nuclear pattern
|
|
|
• develop a lupus like syndrome at a later age and in lower numbers compared to mutant mice wild-type for Tlr7
|
|
|
• increase in anti-RNA IgG levels in the serum at 4 - 6 months of age is less severe than in mutant mice wild-type for Tlr7 and is similar to mice homozygous for Fcgr2btm1Ttk alone
|
renal/urinary system
|
|
• kidney disease is less severe at 5 months of age compared to mutant mice wild-type for Tlr7
|
hematopoietic system
|
|
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
|
|
|
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7
|
growth/size/body
|
|
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
|
