Phenotypes Associated with This Genotype

Genotype
MGI:5487818

• Allelic Composition: Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe
• Genetic Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196270 )

N • untreated mice exhibit normal behavior in SHIRPA analysis

enhanced behavioral response to anesthetic ( J:196270 )

• mice treated with imipramine exhibit pronounced shoulder hunching accompanied by body tremors and spasm compared with wild-type mice that appear sedated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196270 )

N • untreated mice exhibit normal blood plasma biochemical analysis

abnormal physiological response to xenobiotic ( J:196270 )

• mice treated with imipramine exhibit a 2.7-fold increase in serum imipramine levels, an increased imipramine in the kidney, failure to produce imipramine N-oxide and desipramine in the brain compared with wild-type mice