Mouse Genome Informatics
hm
    Cacna1atm3Maag/Cacna1atm3Maag
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization and more frequent peri-infarct depolarizations after filament occlusion of the middle cerebral artery associated with rapid expansion of infarct core on diffusion-weighted magnetic resonance imaging and larger perfusion defects on laser speckle flowmetry
• mutants develop larger areas of cerebral blood flow deficit during distal middle cerebral artery occlusion due to increased susceptibility to ischemic depolarizations
• mutant cortical tissue requires a higher cerebral blood flow threshold level for survival compared to wild-type mice
• transient filament occlusion of the middle cerebral artery for 1 hour produces larger infarcts than in wild-type mice, with more severe cortical, hippocampal, and thalamic involvement

mortality/aging
• mortality rate following filament occlusion of the middle cerebral artery is higher in mutants, reaching 100% within 24 hours after stroke onset

nervous system
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization and more frequent peri-infarct depolarizations after filament occlusion of the middle cerebral artery associated with rapid expansion of infarct core on diffusion-weighted magnetic resonance imaging and larger perfusion defects on laser speckle flowmetry
• mutants develop larger areas of cerebral blood flow deficit during distal middle cerebral artery occlusion due to increased susceptibility to ischemic depolarizations
• mutant cortical tissue requires a higher cerebral blood flow threshold level for survival compared to wild-type mice
• transient filament occlusion of the middle cerebral artery for 1 hour produces larger infarcts than in wild-type mice, with more severe cortical, hippocampal, and thalamic involvement

Mouse Models of Human Disease
OMIM IDRef(s)
Migraine, Familial Hemiplegic, 1; FHM1 141500 J:193793