About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5486304
Allelic
Composition		 Wwtr1tm1Hmc/Wwtr1tm1Hmc
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (17 available)
Wwtr1tm1Hmc mutation (0 available); any Wwtr1 mutation (26 available)
Yap1tm1Hmc mutation (0 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:195266 )
• some of the few proximal tubules present are cystic
abnormal kidney development ( J:195266 )
• developmental defects are similar to mutants wild-type for Wwtr1

growth/size/body
kidney cyst ( J:195266 )
• some of the few proximal tubules present are cystic

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory