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Phenotypes Associated with This Genotype
Genotype
MGI:5486303
Allelic
Composition		 Wwtr1tm1Hmc/Wwtr1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (17 available)
Wwtr1tm1Hmc mutation (0 available); any Wwtr1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Nephrogenesis abnormalities in Wwtr1tm1Hmc/Wwtr1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+, Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ and double mutant mice

renal/urinary system
kidney hemorrhage ( J:195266 )
• spotty hemorrhages are seen at P0
kidney cyst ( J:195266 )
• highly cystic tubules in the cortex at P0

cardiovascular system
kidney hemorrhage ( J:195266 )
• spotty hemorrhages are seen at P0

growth/size/body
kidney cyst ( J:195266 )
• highly cystic tubules in the cortex at P0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory