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Phenotypes Associated with This Genotype
Genotype
MGI:5486124
Allelic
Composition
Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch/0
Tg(tetO-EGFR*L858R)56Hev/0
Genetic
Background
involves: C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch mutation (0 available)
Tg(tetO-EGFR*L858R)56Hev mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• with 12 weeks of continuous doxycycline administration, mice develop widespread tumors in the alveoli, but not in other regions of the lung; tumor cells are highly proliferative

respiratory system
N
• without doxycycline treatment, lung morphology is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory