Phenotypes Associated with This Genotype

Genotype
MGI:5484926

• Allelic Composition: Mlana^tm1.2Bee/Mlana^tm1.2Bee
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

pigmentation phenotype ( J:194886 )

N • mice exhibit normal tail skin, footpad and retina pigmentation

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth

integument

abnormal coat/ hair morphology ( J:194886 )

• reduced number of hairs

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth