Phenotypes Associated with This Genotype

Genotype
MGI:5484772

• Allelic Composition: Cdkal1^Gt(6062)Tgen/Cdkal1^Gt(6062)Tgen
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal lipid accumulation in Cdkal1^Gt(6062)Tgen/Cdkal1^Gt(6062)Tgen mice on a high fat diet

homeostasis/metabolism

increased circulating leptin level ( J:195460 )

• tendency after 20 weeks on a high fat diet

abnormal glucose homeostasis ( J:195460 )

• at early stages, mice fed a high fat diet exhibit less prominent insulin insensitivity and glucose intolerance compared with wild-type mice

• at late stages, mice fed a high fat diet exhibit more prominent insulin insensitivity and glucose intolerance compared with wild-type mice

• however, mice fed standard chow exhibit normal glucose tolerance

decreased insulin secretion ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

• however, circulating insulin levels are normal after 20 weeks on a high fat diet

decreased circulating glucose level ( J:195460 )

• in mice fed a high fat diet for 4 or 8 weeks

• however, circulating glucose levels are normal after 16 or 20 weeks on a high fat diet

decreased circulating insulin level ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

• however, circulating insulin levels are normal after 20 weeks on a high fat diet

decreased liver triglyceride level ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

increased liver triglyceride level ( J:195460 )

• in mice fed a high fat diet for 20 weeks

decreased skeletal muscle triglyceride level ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

increased skeletal muscle triglyceride level ( J:195460 )

• in mice fed a high fat diet for 20 weeks

muscle

decreased skeletal muscle triglyceride level ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

increased skeletal muscle triglyceride level ( J:195460 )

• in mice fed a high fat diet for 20 weeks

adipose tissue

decreased subcutaneous adipose tissue amount ( J:195460 )

• a high fat diet for 8 weeks

• however, fat pad weight is normal at 16 and weeks

decreased abdominal fat pad weight ( J:195460 )

• a high fat diet for 8 weeks

• however, fat pad weight is normal at 16 and weeks

growth/size/body

decreased body weight ( J:195460 )

• at 8, 10 at 11 weeks

• tendency on a high fat diet

behavior/neurological

decreased food intake ( J:195460 )

• tendency in mice fed a high fat diet

endocrine/exocrine glands

decreased insulin secretion ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

• however, circulating insulin levels are normal after 20 weeks on a high fat diet

integument

decreased subcutaneous adipose tissue amount ( J:195460 )

• a high fat diet for 8 weeks

• however, fat pad weight is normal at 16 and weeks

liver/biliary system

decreased liver triglyceride level ( J:195460 )

• in mice fed a high fat diet for 8 or 16 weeks

increased liver triglyceride level ( J:195460 )

• in mice fed a high fat diet for 20 weeks