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Phenotypes Associated with This Genotype
Genotype
MGI:5484737
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1062 available)
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:193452 )
N
• biophysical properties of cholinergic neurons are normal
abnormal nervous system electrophysiology ( J:193452 )
• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons
• similar results with Mc4r agonist THIQ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory