Phenotypes Associated with This Genotype

Genotype
MGI:5484586

• Allelic Composition: Sppl2a^tm1Dgen/Sppl2a^tm1Dgen
• Genetic Background: B6.129P2-Sppl2a^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased myeloid dendritic cell number ( J:194595 )

decreased B cell number ( J:194595 )

• in the spleen

decreased transitional stage T2 B cell number ( J:194595 )

decreased B-1 B cell number ( J:194595 )

decreased follicular B cell number ( J:194595 )

decreased IgA level ( J:194595 )

• prior to immunization

decreased IgG1 level ( J:194595 )

• prior to immunization

• decreased DNP-specific IgG1 after immunization

decreased IgG2b level ( J:194595 )

• prior to immunization

decreased IgG3 level ( J:194595 )

• prior to immunization

• anti-TNP IgM after immunization

decreased IgM level ( J:194595 )

• prior to immunization

• decreased DNP-specific IgM after immunization

• anti-TNP IgM after immunization

hematopoietic system

decreased myeloid dendritic cell number ( J:194595 )

decreased B cell number ( J:194595 )

• in the spleen

decreased transitional stage T2 B cell number ( J:194595 )

decreased B-1 B cell number ( J:194595 )

decreased follicular B cell number ( J:194595 )

decreased IgA level ( J:194595 )

• prior to immunization

decreased IgG1 level ( J:194595 )

• prior to immunization

• decreased DNP-specific IgG1 after immunization

decreased IgG2b level ( J:194595 )

• prior to immunization

decreased IgG3 level ( J:194595 )

• prior to immunization

• anti-TNP IgM after immunization

decreased IgM level ( J:194595 )

• prior to immunization

• decreased DNP-specific IgM after immunization

• anti-TNP IgM after immunization