Phenotypes Associated with This Genotype

Genotype
MGI:5484531

• Allelic Composition: Cd209a^tm1.1Cfg/Cd209a^tm1.1Cfg
• Genetic Background: B6.Cg-Cd209a^tm1.1Cfg/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:194602 )

• in an E. coli sepsis model, LECT2 treatment of mice do not exhibit as much of a rescue of lethality as in wild-type mice

• however, mice receiving LECT2-treated wild-type macrophages exhibit improved survival in an E. coli sepsis model

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:194602 )

• treatment with LECT2 does not rescue E. coli sepsis-induced lethality as well as in wild-type mice

• transfer of macrophages treated with LECT2 do not exhibit reduction in peritoneum and blood bacterial burden as when LECT2-treated wild-type macrophages are transferred

• however, mice receiving LECT2-treated wild-type macrophages exhibit improved survival in an E. coli sepsis model

increased susceptibility to xenobiotic induced morbidity/mortality ( J:194602 )

• in an E. coli sepsis model, LECT2 treatment of mice do not exhibit as much of a rescue of lethality as in wild-type mice

• however, mice receiving LECT2-treated wild-type macrophages exhibit improved survival in an E. coli sepsis model

immune system

immune system phenotype ( J:194602 )

N • LECT2 treatment has no effect on phagocytosis, bacterial killing, G-CSF and C3 secretion from macrophages