Phenotypes Associated with This Genotype

Genotype
MGI:5478622

• Allelic Composition: Col1a1^{tm1(tetO-Yod1*)Hpl}/Col1a1^{tm1(tetO-Yod1*)Hpl}; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:194608 )

N • doxycycline-treated mice exhibit normal T cell distribution in lymphoid organs

abnormal CD8-positive, alpha-beta T cell physiology ( J:194608 )

• CD8+ T cells from doxycycline-treated mice exhibit enhanced response to immunization with viral infection and improved viral growth control compared with control cells

abnormal professional antigen presenting cell physiology ( J:194608 )

• following exposure to ovalbumin, antigen presenting cells (APCs) from doxycycline-treated mice exhibit enhanced antigen cross-production with increased induction of proliferation and IL2 production in OT-I cells compared with control cells

• following infection with MHV-68 and irradiation, bone marrow derived dendritic cells from doxycycline-treated mice prime more effective CD8+ T cell response compared with control cells

• APCs from doxycycline-treated mice exhibit prolonged antigen retention compared with control cells

• cross-presentation in doxycycline-treated mice requires acidification and is insensitive to brefeldin compared to in control cells

• however, antigen presentation in doxycycline-treated mice is normal

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:194608 )

• CD8+ T cells from doxycycline-treated mice exhibit enhanced response to immunization with viral infection and improved viral growth control compared with control cells