Phenotypes Associated with This Genotype

Genotype
MGI:5478541

• Allelic Composition: Kcnq5^tm1.1Tjj/Kcnq5^tm1.1Tjj
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:195336 )

• both heterozygotes and homozygotes are born at less than expected ratios

• postnatal development and lifespan are normal

nervous system

abnormal afterhyperpolarization ( J:195336 )

• apamin insensitive medium AHPis unaffected CA1 neurons of the hippocampus but reduced 50% in CA3

• change transfer slow AHP and sAHP amplitude are decreased 25-30% in CA3 neurons