Phenotypes Associated with This Genotype

Genotype
MGI:5477915

• Allelic Composition: Gja1^tm10Kwi/Gja1^tm10Kwi; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:194957 )

• all mice die on the first day after birth

cardiovascular system

cardiovascular system phenotype ( J:194957 )

N • mice exhibit normal heart beating frequency, PQ duration and QRS amplitude

abnormal myocardial trabeculae morphology ( J:194957 )

• minor thickening and irregularities in the right ventricle

abnormal cardiac outflow tract development ( J:194957 )

• abnormal pouch formation at the subpulmonary outflow tract

• however, the outflow tract is open in neonates

prolonged QRS complex duration ( J:194957 )

• 3-fold at E16.5

muscle

abnormal myocardial trabeculae morphology ( J:194957 )

• minor thickening and irregularities in the right ventricle