Mouse Genome Informatics
hm
    Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Polycystic kidney disease in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha mice

renal/urinary system
• multiple ductal plate malformations, such as microhamartomas, in most mice by 12 months
• kidney volume increases progressively over time until 12 months of age
• increases progressively over time until 12 months of age
• mice develop mild but progressive polycystic kidney disease
• as early as E16.5
• at P1, cysts arise primarily from the proximal tubule
• at 3 months, cysts arise primarily from the collecting duct
• at 3 months, cysts range form 0.3 to 2.5 mm
• cyst burden varies but increased with time
• increases over time

homeostasis/metabolism

tumorigenesis
• multiple ductal plate malformations, such as microhamartomas, in most mice by 12 months

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:193544