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Phenotypes Associated with This Genotype
Genotype
MGI:5476836
Allelic
Composition
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Polycystic kidney disease in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha mice

renal/urinary system
• multiple ductal plate malformations, such as microhamartomas, in most mice by 12 months
• multiple ductal plate malformations, such as microhamartomas, in most mice by 12 months
• kidney volume increases progressively over time until 12 months of age
• increases progressively over time until 12 months of age
• mice develop mild but progressive polycystic kidney disease
• as early as E16.5
• at P1, cysts arise primarily from the proximal tubule
• at 3 months, cysts arise primarily from the collecting duct
• at 3 months, cysts range form 0.3 to 2.5 mm
• cyst burden varies but increased with time
• increases over time

homeostasis/metabolism

neoplasm
• multiple ductal plate malformations, such as microhamartomas, in most mice by 12 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:193544


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory