Mouse Genome Informatics
tg
    Tg(Eno2-MFN2*R94Q)L51Ugfm/Tg(Eno2-MFN2*R94Q)L51Ugfm
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• mice exhibit normal cerebellum morphology (J:173431)
• at 12 months, the proportion of small and medium axons is increased while proportion of large axons is decreased compared to in control mice
• the component area to amplitude ratio generated by small-medium fibers Adelta is increased compared to in control nerves

behavior/neurological
• at 5 months with homogenous phenotype

cellular
• in medium and small myelinated axons at 12 months
• however, large axons exhibit normal numbers of mitochondria

Mouse Models of Human Disease
OMIM IDRef(s)
Charcot-Marie-Tooth Disease, Axonal, Type 2A2; CMT2A2 609260 J:173431