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Phenotypes Associated with This Genotype
Genotype
MGI:5475128
Allelic
Composition		 Gpr161tm1Lex/Gpr161tm1Lex
Smotm1Amc/Smotm1Amc
Genetic
Background		 involves: 129S/SvEv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161tm1Lex mutation (1 available); any Gpr161 mutation (30 available)
Smotm1Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:193395 )
• similar to Gpr161 single mutants

embryo
abnormal neural tube morphology ( J:193395 )
• neural tube is ventralized similar to Gpr161 single mutants

growth/size/body
growth/size/body region phenotype ( J:193395 )
N
• unlike in Smo single mutants, growth retardation is not seen at E9.5

nervous system
abnormal neural tube morphology ( J:193395 )
• neural tube is ventralized similar to Gpr161 single mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory