Phenotypes Associated with This Genotype

Genotype
MGI:5475127

• Allelic Composition: Gpr161^tm1Lex/Gpr161^tm1Lex
• Genetic Background: involves: 129S/SvEv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193395 )

• at E10.5

craniofacial

abnormal craniofacial morphology ( J:193395 )

• extensive craniofacial abnormalities at E10.5

• abnormalities are detected as early as the 8-10 somite stage

limbs/digits/tail

abnormal limb development ( J:193395 )

• no sign of limb morphogenesis by E10

absent apical ectodermal ridge ( J:193395 )

• at E10

embryo

embryo phenotype ( J:193395 )

N • at E10 morphology of primary cilia is similar to wild-type controls

abnormal dorsal-ventral axis patterning ( J:193395 )

• defects in dorsal ventral patterning are detected as early as the 8-10 somite stage

absent apical ectodermal ridge ( J:193395 )

• at E10

abnormal neural tube morphology ( J:193395 )

• expression analysis indicates the neural tube is ventralized throughout the spinal cord and hindbrain regions

enlarged floor plate ( J:193395 )

• expansion of the floor plate progenitor domain

spina bifida ( J:193395 )

• spinal cord is open in the most caudal regions

nervous system

abnormal neural tube morphology ( J:193395 )

• expression analysis indicates the neural tube is ventralized throughout the spinal cord and hindbrain regions

enlarged floor plate ( J:193395 )

• expansion of the floor plate progenitor domain

spina bifida ( J:193395 )

• spinal cord is open in the most caudal regions

exencephaly ( J:193395 )

• open forebrain/midbrain regions at E9.5