Phenotypes Associated with This Genotype

Genotype
MGI:5475021

• Allelic Composition: Tg(Lck-Tnfsf4)1Nish/0
• Genetic Background: C.Cg-Tg(Lck-Tnfsf4)1Nish

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:194882 )

N • Background Sensitivity: mice on the BALB/c background do not develop vascular lesions in the lungs, vasoconstriction in pulmonary arteries, an increase in right ventricular systolic pressure, or right ventricle hypertrophy as seen in mice on a C57BL/6 background

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:194882 )

• increase in the number of effector/memory CD4+ T cells in the spleen and lungs

• Background Sensitivity: the number of IL-17 producing CD4+ T cells in response to PMA/ionomycin stimulation is increased in 8-10 week old mutants but to a much lower extent than on the C57BL/6 background

increased regulatory T cell number ( J:194882 )

• Background Sensitivity: the frequency and absolute number of T regulatory cells is increased at 8-10 weeks of age; this increase is less on the C57BL/6 than on the BALB/c background

abnormal CD4-positive, alpha-beta T cell physiology ( J:194882 )

• Background Sensitivity: IL-13 production by CD4+ T cells in the lungs in response to anti-CD3 stimulation is increased in 8-10 week old mice; this increase is greater on the C57BL/6 background than on the BALB/c background

• Background Sensitivity: the number of IL-17 producing CD4+ T cells in response to PMA/ionomycin stimulation is increased in 8-10 week old mutants but to a much lower extent than on the C57BL/6 background

immune system

increased CD4-positive, alpha-beta T cell number ( J:194882 )

• increase in the number of effector/memory CD4+ T cells in the spleen and lungs

• Background Sensitivity: the number of IL-17 producing CD4+ T cells in response to PMA/ionomycin stimulation is increased in 8-10 week old mutants but to a much lower extent than on the C57BL/6 background

increased regulatory T cell number ( J:194882 )

• Background Sensitivity: the frequency and absolute number of T regulatory cells is increased at 8-10 weeks of age; this increase is less on the C57BL/6 than on the BALB/c background

abnormal CD4-positive, alpha-beta T cell physiology ( J:194882 )

• Background Sensitivity: IL-13 production by CD4+ T cells in the lungs in response to anti-CD3 stimulation is increased in 8-10 week old mice; this increase is greater on the C57BL/6 background than on the BALB/c background

• Background Sensitivity: the number of IL-17 producing CD4+ T cells in response to PMA/ionomycin stimulation is increased in 8-10 week old mutants but to a much lower extent than on the C57BL/6 background

increased interleukin-13 secretion ( J:194882 )

• Background Sensitivity: IL-13 production by CD4+ T cells in the lungs in response to anti-CD3 stimulation is increased in 8-10 week old mice; this increase is greater on the C57BL/6 background than on the BALB/c background

respiratory system

respiratory system phenotype ( J:194882 )

N • Background Sensitivity: mice on the BALB/c background do not develop vascular lesions in the lungs or vasoconstriction in pulmonary arteries as seen in mice on a C57BL/6 background