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Phenotypes Associated with This Genotype
Genotype
MGI:5474627
Allelic
Composition		 Ier3tm1Mxw/Ier3tm1Mxw
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ier3tm1Mxw mutation (1 available); any Ier3 mutation (10 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:194587 )
• dextran sulfate sodium induced colitis is more severe than in either single homozygote but less severe than in wild-type controls

immune system
decreased susceptibility to induced colitis ( J:194587 )
• dextran sulfate sodium induced colitis is more severe than in either single homozygote but less severe than in wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory