Phenotypes Associated with This Genotype

Genotype
MGI:5474353

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mir21)Jake}/Gt(ROSA)26Sor⁺; Tg(Gfap-cre)#Mvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are smaller and have thinner processes compared to astrocytes in injured wild-type mice

increased susceptibility to injury ( J:192021 )

• lesion size is increased approximately 80% compared to wild-type mice following severe spinal cord injury

nervous system

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are smaller and have thinner processes compared to astrocytes in injured wild-type mice

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is reduced compared to injured wild-type controls

cellular

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are smaller and have thinner processes compared to astrocytes in injured wild-type mice

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is reduced compared to injured wild-type controls