Phenotypes Associated with This Genotype

Genotype
MGI:5474007

• Allelic Composition: Col1a1^{tm2(tetO-CTNNB1*)Hoch}/Col1a1^{tm2(tetO-CTNNB1*)Hoch}; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:191050 )

• suppressed cellular differentiation toward goblet cells

abnormal intestinal epithelium morphology ( J:191050 )

• after doxycycline treatment of adults

• number of intestinal stem cells is increased

• decreased cell division in colonic cells

abnormal crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission and budding is normalized after treatment with notch inhibitors

abnormal large intestine crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission is often observed in the large intestine

abnormal small intestine crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission is often observed in the small intestine

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission and budding is normalized after treatment with notch inhibitors

abnormal large intestine crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission is often observed in the large intestine

abnormal small intestine crypts of Lieberkuhn morphology ( J:191050 )

• crypt fission is often observed in the small intestine

cellular

abnormal intestinal goblet cell morphology ( J:191050 )

• suppressed cellular differentiation toward goblet cells