Analysis Tools
respiratory system
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 60% decrease of vWF+ intraacinous vessels in lungs at P14, indicating inhibition of pulmonary vascular development
• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 70% increase in muscularization of pulmonary vessels, a 2-fold increase in medial wall thickness of vessels, and increased vessels with proliferating cells in the lungs, indicating pulmonary vascular remodeling
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit increased inflammatory cell infiltration in alveolar air spaces and perivascular regions of lungs, with a 9-fold increase in macrophage infiltration
• pups nursing on dams administered doxycycline from P1 to P14 exhibit an increase in macrophage and neutrophil counts and the presence of numerous multinucleated giant cells in bronchoalveolar lavage (BAL) fluids
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit larger and simplified alveoli with fewer secondary septa compared to controls at P7 and P14
• pups nursing on dams administered doxycycline from P1 to P14 show a 30% and 50% increase in mean linear intercept in lungs at P7 and P14, respectively and a 60% reduction in radial alveolar count at P14
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit simplified alveoli with fewer secondary septa compared to controls at P7 and P14
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cardiovascular system
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 60% decrease of vWF+ intraacinous vessels in lungs at P14, indicating inhibition of pulmonary vascular development
• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 70% increase in muscularization of pulmonary vessels, a 2-fold increase in medial wall thickness of vessels, and increased vessels with proliferating cells in the lungs, indicating pulmonary vascular remodeling
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit an increase in the ratio of right ventricle over left ventricle plus septum compared to controls, indicating hypertrophic right ventricles
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit a higher right ventricular systolic pressure compared to controls
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• pups nursing on dams administered doxycycline from P1 to P14 develop pulmonary hypertension as indicated by increased right ventricle systolic pressure and right ventricular hypertrophy
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immune system
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit increased inflammatory cell infiltration in alveolar air spaces and perivascular regions of lungs, with a 9-fold increase in macrophage infiltration
• pups nursing on dams administered doxycycline from P1 to P14 exhibit an increase in macrophage and neutrophil counts and the presence of numerous multinucleated giant cells in bronchoalveolar lavage (BAL) fluids
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muscle
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit an increase in the ratio of right ventricle over left ventricle plus septum compared to controls, indicating hypertrophic right ventricles
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growth/size/body
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• pups nursing on dams administered doxycycline from P1 to P14 exhibit an increase in the ratio of right ventricle over left ventricle plus septum compared to controls, indicating hypertrophic right ventricles
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lower respiratory tract disease | DOID:0050161 | J:171151 | ||
